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  • Dr. Umakanta Subudhi, Sr. Scientist 9938672226,   usubudhi@immt.res.in ,  

    DESCRIPTION :

    Dr. Umakanta Subudhi is working as a Scientist in CSIR-IMMT since 7th August, 2009. He obtained M.Sc. Biotechnology from Utkal University in the year 2002 and continued there for Ph.D. under the guidance of Prof. G.B.N. Chainy, FNASc. Dr Subudhi is the pioneer in curcumin research with respect to thyroid disorders. His work on antioxidant role of vitamin E and curcumin in general and curcumin in particular to the hypo-and hyperthyroid rat model is of great importance. Oral administration of curcumin combats oxidative stress and positively regulates antioxidant gene expression in altered thyroid states. Nonetheless, for the first time in the Utkal University two molecular techniques like RT-PCR and Western Blot to study gene expression have been introduced by Dr Subudhi and since 2006 these techniques are used routinely in the Department of Biotechnology. Apart from the major doctoral thesis he contributed to the field of chemico-biological interactions and metal ion interaction with Nucleic acids. These initial hands-on experience made him more interested in understanding the relationship between Nucleic acids structure and function. Particularly he explored the selective binding between primer of specific genes to its complementary sequences for generating self-assembled branched DNA nanostructures. This concept of explicit interaction leads him to the field of DNA Nanotechnology.


    EXPERIENCE :
    • Scientist (07.08.2012 to till date).
    • Asst. Professor (07.08.2012 to till date).
    • Junior Scientist (07.08.2009 to 06.08.2012).
    AREA OF INTEREST :
    • DNA Nanotechnology & Application.
    AWARDS & HONOURS :
    • CSIR-Young Scientist Award 2016 in Biological Sciences by the Council of Scientific & Industrial Research, Government of India.
    • Odisha Young Scientist Award 2010 in Life Sciences by the Odisha Bigyan Academy, Ministry of Science & Technology, Government of Odisha.
    • Senior Research Fellowship (ICMR-SRF) 2008 by the Indian Council of Medical Research, Government of India.
    • Junior Research Fellowship (DBT-JRF) 2004 by the Department of Biotechnology, Government of India.
    • Post Graduate Fellowship (2002-2004) by the Department of Biotechnology, Government of India through CEEB conducted by Jawaharlal Nehru University, New Delhi.
    RECENT PUBLICATIONS :
    • S. Majumder, Mishra I, U. Subudhi, S. Varma. Enhanced biocompatibility for plasmid DNA on patterned TiO2 surfaces. Appl. Phys. Lett. 103: 63103, 2013.
    • U. Subudhi, G.B.N. Chainy. Curcumin and vitamin E modulate hepatic antioxidant gene expression in PTU-induced hypothyroid rats. Mol. Biol. Rep. 39:9849-9861, 2012.
    • U. Subudhi, G.B.N. Chainy. Expression of hepatic antioxidant genes in L-thyroxine-induced hyperthyroid rats: Regulation by vitamin E and curcumin. Chem. Biol. Interact. 183: 304-316, 2010.
    • S. Majumder, M. Priyadarshini, U. Subudhi, G.B.N. Chainy, S. Varma. X-ray photoelectron spectroscopic investigations of modifications in plasmid DNA after interaction with Hg nanoparticles. Appl. Surf. Sci. 256: 438-442, 2009.
    • S. Majumder, M. Priyadarshini, U. Subudhi, M. Umananda, G.B.N. Chainy, P.V. Satyam, S. Varma. Fabrication, photoemission studies and sensor of Hg nanoparticles templated on plasmid DNA. Appl. Phys. Lett. 94: 073110, 2009.
    • A.K. Nayak, U. Subudhi. Directed self-assembly of genomic sequences into monomeric and polymeric branched DNA structures. RSC Advances 4: 54506-54511, 2014.
    • A.K. Nayak, A. Mishra, B.S. Jena, B.K. Mishra, U. Subudhi. Lanthanum induced B-to-Z transition in self-assembled Y-shaped branched DNA structure. Nature Scientific Reports, 6: 26855-26867, 2016.
    • M.M. Bhanjadeo, A.K. Nayak, U. Subudhi. Cerium chloride stimulated controlled conversion of B-to-Z-DNA in self-assembled nanostructures. Biochem. Biophys. Res. Commun., 482: 916-921, 2017.
    • M.M. Bhanjadeo, A.K. Nayak, U. Subudhi. Surface-assisted DNA self-assembly: An enzyme-free strategy towards formation of branched DNA lattice. Biochem. Biophys. Res. Commun., 485: 492-498, 2017.
    • S. Nahar, A.K. Nayak, A. Ghosh, U. Subudhi, S. Maiti. Enhanced and synergistic downregulation of oncogenic miRNAs by self-assembled branched DNA. Nanoscale, 10: 195-202, 2018.