DESCRIPTION :

Dr. T. Pavan Kumar currently working as Senior Scientist in the Department of R&D Planning and Business Development at CSIR-Institute of Minerals & Materials Technology, Bhubaneswar, India. He obtained his B.Sc Chemistry in 2002 with college first and M.Sc Organic Chemistry in 2004 from Osmania University, Hyderabad and secured university first with four gold medals. He pursued his Ph.D work in Chemistry at CSIR-IICT  as CSIR-JRF/SRF and received Ph.D degree from Osmania University, Hyderabad  in 2011. Following his Ph.D, he worked for an IP company (Dolcera) for about 2 years and then got selected for Inspire Faculty Award from DST in 2012. He again worked at CSIR-IICT, Hyderabad as Inspire Faculty & Assistant Professor-AcSIR for about 5 years. He holds PGDPL (Patents Law) from NALSAR, Hyderabad and several certifications from WIPO. He was a visiting fellow (Post Doc) at NDSU, USA in 2015 and also associated with NRDC, New Delhi as Manager-IP&TT for s short stint in 2016-2017. Before joining CSIR-IMMT, he was Assistant Professor at TGASC, Puducherry. His research interests includes Organic Chemistry, Asymmetric Synthesis, Process Chemistry, Medicinal Chemistry, Small Molecules Chemistry, Green Chemistry. He has vast experience in Intellectual Property (Patents) and has about 18 patents to his credit.  

He is a associate fellow of Andhra Pradesh Akademi of Sciences,  life member of the Chemical Research Society of India, Material Research Society of India, Global Intellectual Property Convention,  Indian Society of Chemists & Biologists, and the Indian Science Congress Association. His present research work is focused on small molecule chemistry with biology interface and process chemistry and his core functioning is in the areas of Intellectual Property and Technology Management & Business Development.

·         Basic Research: Organocatalysis-Asymmetric Synthesis; Nucleic Acid Chemistry; Process Chemistry, Medicinal Chemistry; Natural Product Synthesis & Flow Chemistry

·         IP Management & Business development: Patent  searches and analytics using various databases/STN Search and Markush Structure Analysis/Patent Drafting and Portfolio-Management

·         Academic Teaching: Organic Chemistry Courses and Intellectual Property (IP), Patent Search and Analytics

·         Technology Development: Process/Technology Development and Demonstration, Client management, Project execution and monitoring, Documentation and Result submission etc.

1.   Enantioselective Michael addition of aldehydes to nitroolefinscatalyzed by pyrrolidine-HOBt: Togapur Pavan Kumar*, Mohammad Abdul Sattar, Sthanikam Siva Prasad, Kothapalli Haribabu, Cirandur Suresh Reddy(Tetrahedron: Asymmetry, 2017, 28, 401-409).

2.      Pyrrolidine-HOBt: an oxytriazole catalyst for the enantioselective Michael addition of cyclohexanone to nitroolefins in water:Togapur Pavan Kumar*, Sthanikam Siva Prasad Kothapalli Haribabu, Veerjala Naveen Kumar Cirandur Suresh Reddy(Tetrahedron: Asymmetry, 2016, 27, 1133-1138).

3.   Chiral Pyrrolidine-Pyrazole Catalyzed Enantioselective Michael Addition: a Mechanistic Study by Computational Methods: Ramesh Kumar Chitumalla,Pavan Kumar Togapur and Joonkyung Jang* (Bull. Korean Chem. Soc, 2016, 37, 1554-1555).

4.    Asymmetric aldol reaction of isatins catalyzed by phthalimido-prolinamide: Togapur Pavan Kumar*, Nemali Manjula, Kumar Katragunta(Tetrahedron: Asymmetry, 2015, 26, 1281-1284).

5. Pyrrolidine-oxyimide catalyzed asymmetric Michael addition of α,α-disubstituted aldehydes to nitroolefins: TogapurPavan Kumar*(Tetrahedron: Asymmetry, 2015, 26,907-911).

6.      Myrtanyl-prolinamide: a new chiral organocatalyst for stereoselectivealdol reactions Togapur Pavan Kumar*, Rapelli Chandra Shekhar, KondepudiSugnanaSunder, RajeshVadaparthi(Tetrahedron: Asymmetry, 2015, 26,543-547).

7.  Pyrrolidine-oxyimides: new chiral catalysts for enantioselective Michael addition of ketones to nitroolefins in water: TogapurPavan Kumar*, LaghuvarapuRadhika, KothapalliHaribabu, Veerjala Naveen Kumar (Tetrahedron: Asymmetry, 2014, 25,1555-1560).

8.     AZT-prolinamide: the nucleoside derived pyrrolidine catalysts for asymmetric aldol reactions in water: TummaNaresh, TogapurPavan Kumar, KothapalliHaribabu, Srivari Chandrasekhar*(Tetrahedron: Asymmetry, 2014, 25,1340-1345).

9. Intellectual Property Rights-Patents and their application procedures:TogapurPavan Kumar*(Proceedings of APAS, Special Issue on Science for Society, December2014, 16, 29-42).

10. Asymmetric Michael addition of aldehydes to nitroolefins catalyzed by pyrrolidine-pyrazole: TogapurPavan Kumar*(Tetrahedron: Asymmetry, 2014, 25,1286-1291).

11. Enantioselective Michael addition of α,α-disubstituted aldehydes to nitroolefins catalyzed by pyrrolidine-pyrazole: TogapurPavan Kumar*, KothapalliHaribabu (Tetrahedron: Asymmetry, 2014, 25, 1129-1132).

12.  PeptidomimeticOragnocatalysts: Efficient Michael addition onto Nitroolefins with very low catalyst loading: S. Chandrasekhar*, Ch. Praveen Kumar, T. Pavan Kumar, K. Haribabu, B. Jagadeesh*, J. K. Lakshmi, Prathama S Mainkar*(RSC Advances, 2014, 4, 33025-33031).

13.  Phthalimido-prolinamide: a new chiral catalyst for solvent free enantioselective aldol reaction; Togapur Pavan Kumar*,NamdevraoChethanVavle, Vidyavathi Patro, Kothapalli Haribabu(Tetrahedron: Asymmetry, 2014, 25, 457-461).

14.  Sugar amide-pyrrolidine catalyst for asymmetric Michael addition of ketones to nitroolefins; Togapur Pavan Kumar*,SirinyamVenugopalBalaji(Tetrahedron: Asymmetry2014, 25, 473-477). 

15.  Direct asymmetric Michael addition of ketones to chalconescatalyzed by hydroxyphthalimide derived triazole-pyrrolidine; Togapur Pavan Kumar*, Mohammad Abdul Sattar, Vanka Uma MaheshwaraSarma(Tetrahedron: Asymmetry,2013, 24, 1615-19). 

16.  Asymmetric synthesis of all stereoisomers of 3-hydroxyproline: The constituent of several bioactive compounds: Togapur Pavan Kumar, Srivari Chandrasekhar*(Synthesis,2012, 44, 2889).

17.  First acid-catalyzed entry to O-alkylated hydroximides from benzylic alcohols: Srivari Chandrasekhar, Laghuvarapu Radhika, Togapur Pavan Kumar and Chada Raji Reddy* (European Journal of Organic Chemistry, 2011, 30, 5967-5970). 

18.  Chiral pyrrolidine-pyrazole catalyst for enantioselective Michael addition of carbonyls to nitroolefins: Srivari Chandrasekhar*, Togapur Pavan Kumar, Kothapalli Haribabu, Chada Raji Reddy, Chittumalla Ramesh Kumar (Tetrahedron:Asymmetry, 2011, 22, 697-702). 

19.  Hydroxyphthalimide allied triazole-pyrrolidine catalyst for Michael addition in water: Srivari Chandrasekhar*,TogapurPavan Kumar, KothapalliHaribabu, ChadaRaji Reddy (Tetrahedron:Asymmetry, 2010, 21, 2372-2375).

20. Hydroxylamine derivatives as nucleophiles in Ferrier glycosylation: Synthesis of aminoxpseudoglycals: Ch. Raji Reddy*, Y.S. Rao, T. Pavan Kumar, K.V. Reddy and S. Chandrasekhar (Synthesis, 2008, 1, 122-126).

1.    Synthesis and biological evaluation of mitochondria-targeted esculetin for its anti-atherosclerotic and age delaying effects: KotamrajuSrigiridhar, Santosh Kumar, TogapurPavan Kumar, B. V. S. Reddy, Mahesh Kumar (Indian Patent Application No: 478/DEL/2015; US Publication No:US20160244470A1; GB Application No: P1013151GB)

2.  Oxy imido triazoles and oxime ethers from hydroxylamine derivatives: Srivari Chandrasekhar, Togapur Pavan Kumar, VidyavathiPatro, Prathama S Mainkar, ChadaRaji Reddy (Indian Patent Application No: 201611000697).

3.     A process for the preparation of nicotine: Prathama S Mainkar,KondepudiSugnana Sunder, Togapur Pavan Kumar, Srivari Chandrasekhar (Indian Patent Application No: 201611002388; PCT Publication No: WO2017/119003; EP Application No: 17707968.8).

4.   Spirooxindole compounds as GSK3 inhibitors and process for preparation thereof: Prathama S Mainkar, Mohammad Abdul Sattar, Mallesham, Togapur Pavan Kumar, Ummanni Ramesh, DivyaDuscharla, Srivari Chandrasekhar (Indian Patent Application No: 201611008487; PCT Application No: PCT/IN2018/050134).

5.      An improved process for the production of lipoic acid: Srivari Chandrasekhar, Togapur Pavan Kumar, KondepudiSugnana Sunder, Vanka Uma MaheshwaraSarma, Prathama S Mainkar (Indian Patent Application No: 201811016688).

6.   Isothiocyanate compounds as SMAR1 stabilizers: Srivari Chandrasekhar, Togapur Pavan Kumar, Prathama S Mainkar, SamitChatopadhyay, Shruti Joshi, Venkatraju Chippala(Indian Patent Application No: 201611028762).

7.    Nimbolide derivatives as anticancer agents and their preparation thereof: Srivari Chandrasekhar, Prathama S Mainkar, KarreNagaraju,Togapur Pavan Kumar, , Ummani Ramesh, KanchanapalliTejaswini, K. Suresh Babu, B S Sastry, DebabrataMukhopadhyay(Indian Patent Application No: 201811000561).

8. Indole (sulfomyl) N-hydroxy benzamide derivatives as selectiveHDAC inhibitors:Srivari Chandrasekhar, Prathama S Mainkar, Chada Raji Reddy, KotamrajuSrigiridhar, Togapur Pavan Kumar, Muppidi Mohan Venkata Subbarao, somesh Sharma, Ashok Kumar Jha, PremkumarArumugam(Indian Patent Application No: 201711042426; PCT Application No: PCT/IN2018/050514).

9.   Process for the preparation of zafirlukast and analogs theeof: Srivari Chandrasekhar, Paladugu Srinu, Prathama S Mainkar , Togapur Pavan Kumar, (Indian Patent Application No: 201711046976; PCT Application No: PCT/IN2018/050513).

TPP-Esculatin Derivatives   (while working at CSIR-IICT)  - Patent out licensing to SUN Pharma in 2019